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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2decreases expressionISOESR2 (Homo sapiens)6480464CTDCisplatin results in decreased expression of ESR2 mRNAPMID:23956100
Esr2increases response to substanceISOESR2 (Homo sapiens)6480464CTDESR2 protein results in increased susceptibility to CisplatinPMID:20623183
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDESR2 protein inhibits the reaction [Cisplatin results in increased expression of and results in increased phosphorylation of CDC25C protein]; ESR2 protein inhibits the reaction [Cisplatin results in increased expression of BRCA1 mRNA]; ESR2 protein inhibits the reaction [Cisplatin results in increased expression of BRCA1 protein]; ESR2 protein inhibits the reaction [Cisplatin results in increased phosphorylation of CHEK1 protein]; ESR2 protein promotes the reaction [Cisplatin results in increased expression of CASP2 protein]; ESR2 protein promotes the reaction [Cisplatin results in increased expression of CASP3 protein]; TP53 protein inhibits the reaction [ESR2 protein results in increased susceptibility to Cisplatin]PMID:20623183
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