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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:17846
Term: (S)-naringenin
Definition: The (S)-enantiomer of naringenin.
Chemical ID: MESH:C005273
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2affects bindingEXP 6480464CTDnaringenin binds to ESR2 proteinPMID:19913605
Esr2affects bindingISOEsr2 (Mus musculus)6480464CTDnaringenin binds to ESR2 proteinPMID:19913605
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDnaringenin binds to ESR2 proteinPMID:12224631 PMID:16566672 PMID:19913605
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDnaringenin results in increased activity of ESR2 proteinPMID:16118406 PMID:17716812
Esr2increases expressionISOESR2 (Homo sapiens)6480464CTDnaringenin metabolite results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 mRNA; naringenin results in increased expression of ESR2 proteinPMID:30153467 PMID:36235125
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTD[Tamoxifen co-treated with naringenin] results in increased expression of ESR2 mRNA; [Tamoxifen co-treated with naringenin] results in increased expression of ESR2 protein; bisphenol A inhibits the reaction [naringenin metabolite results in increased expression of ESR2 mRNA]; bisphenol A inhibits the reaction [naringenin results in increased expression of ESR2 mRNA]; naringenin binds to and results in increased activity of ESR2 protein; naringenin inhibits the reaction [Estradiol binds to ESR2 protein]PMID:16566672 PMID:30153467 PMID:36235125 PMID:9751507
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