GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects binding | EXP | | 6480464 | CTD | nonylphenol binds to ESR1 protein | PMID:11086226 | Esr1 | increases activity | EXP | | 6480464 | CTD | nonylphenol results in increased activity of ESR1 protein | PMID:12504345 | Esr1 | increases expression | EXP | | 6480464 | CTD | nonylphenol results in increased expression of ESR1 mRNA; nonylphenol results in increased expression of ESR1 protein | PMID:11731036 PMID:12062901 PMID:34464681 | Esr1 | affects activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | nonylphenol affects the activity of ESR1 protein | PMID:18635651 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | nonylphenol analog binds to ESR1 protein; nonylphenol binds to ESR1 protein; nonylphenol metabolite binds to ESR1 protein | PMID:10492897 PMID:14579009 PMID:19720131 PMID:20074635 PMID:22467034 PMID:22941308 PMID:28280777 | Esr1 | affects localization | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | nonylphenol affects the localization of ESR1 protein | PMID:27260121 | Esr1 | decreases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | nonylphenol analog results in decreased expression of ESR1 mRNA; nonylphenol analog results in decreased expression of ESR1 protein | PMID:25242005 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | nonylphenol results in decreased expression of ESR1 mRNA; nonylphenol results in decreased expression of ESR1 protein | PMID:14709801 PMID:14754635 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | nonylphenol analog results in increased activity of ESR1 protein; nonylphenol results in increased activity of ESR1 protein | PMID:14975756 PMID:16756374 PMID:29066353 | Esr1 | increases expression | ISO | Esr1 (Mus musculus) | 6480464 | CTD | nonylphenol analog results in increased expression of ESR1 mRNA; nonylphenol analog results in increased expression of ESR1 protein | PMID:25242005 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | nonylphenol results in increased expression of ESR1 mRNA | PMID:26224478 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [nonylphenol binds to ESR1 protein] which results in increased activity of ALPL protein; [nonylphenol results in increased activity of ESR1 protein] which results in increased expression of CTSD mRNA; [nonylphenol results in increased activity of ESR1 protein] which results in increased expression of TFF1 mRNA; afimoxifene inhibits the reaction [nonylphenol results in increased activity of ESR1 protein]; ESR1 protein promotes the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]; Fulvestrant inhibits the reaction [nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]]; nonylphenol analog inhibits the reaction [Estradiol binds to ESR1 protein]; nonylphenol analog inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; nonylphenol binds to and results in increased activity of ESR1 protein; nonylphenol inhibits the reaction [Estradiol binds to ESR1 protein]; nonylphenol promotes the reaction [ESR1 protein binds to CTSD promoter]; nonylphenol results in increased activity of and results in increased localization of ESR1 protein; TGFB3 protein inhibits the reaction [nonylphenol results in increased expression of ESR1 mRNA] | PMID:12650720 PMID:14579009 PMID:14709801 PMID:14754635 PMID:19720131 PMID:20362049 PMID:20435135 PMID:26224478 PMID:27366082 PMID:29066353 PMID:33049310 PMID:9751507 | | ||||||||||||||||||||||
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