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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:75417
Term: dibenzoylmethane
Definition: A beta-diketone that is acetylacetone (acac) in which both methyl groups have been replaced by phenyl groups. It is a minor constituent of the root extract of licorice (Glycyrrhiza glabra) and exhibits antimutagenic and anticancer effects.
Chemical ID: MESH:C061481
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDdibenzoylmethane inhibits the reaction [ESR1 protein binds to BCL2 enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to MYC enhancer]; dibenzoylmethane inhibits the reaction [ESR1 protein binds to TERT enhancer]PMID:16051634
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