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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:35004
Term: Tetrachlorobisphenol A
Definition: A bisphenol that has formula C15H12Cl4O2.
Chemical ID: MESH:C041181
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDtetrachlorodian binds to ESR1 proteinPMID:12753421
Esr1affects expressionISOESR1 (Homo sapiens)6480464CTDtetrachlorodian affects the expression of ESR1 mRNAPMID:33582643
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDtetrachlorodian results in increased activity of ESR1 proteinPMID:21561829 PMID:31388671
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDtetrachlorodian results in increased expression of ESR1 proteinPMID:33582643
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDtetrachlorodian binds to and results in increased activity of ESR1 protein; tetrachlorodian inhibits the reaction [Coumestrol binds to ESR1 protein modified form]PMID:21622942 PMID:23714657 PMID:29152682 PMID:33049310
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