GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects binding | ISO | Esr1 (Mus musculus) | 6480464 | CTD | butylbenzyl phthalate binds to ESR1 protein | PMID:19913605 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | butylbenzyl phthalate binds to ESR1 protein | PMID:19913605 PMID:20822795 PMID:22467034 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | butylbenzyl phthalate results in decreased expression of ESR1 mRNA; butylbenzyl phthalate results in decreased expression of ESR1 protein | PMID:30851587 | Esr1 | decreases methylation | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | butylbenzyl phthalate results in decreased methylation of ESR1 gene; butylbenzyl phthalate results in decreased methylation of ESR1 promoter | PMID:16326419 PMID:22949852 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | butylbenzyl phthalate results in increased activity of ESR1 protein | PMID:28571686 | Esr1 | multiple interactions | ISO | Esr1 (Mus musculus) | 6480464 | CTD | [diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ESR1 mRNA | PMID:28013214 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | butylbenzyl phthalate binds to and results in increased activity of ESR1 protein; butylbenzyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Oxygen deficiency promotes the reaction [butylbenzyl phthalate results in decreased expression of ESR1 mRNA]; Oxygen deficiency promotes the reaction [butylbenzyl phthalate results in decreased expression of ESR1 protein]; Tamoxifen inhibits the reaction [butylbenzyl phthalate binds to and results in increased activity of ESR1 protein] | PMID:15840436 PMID:28571686 PMID:29162470 PMID:30851587 PMID:33049310 | |
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