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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:34595
Term: Butylbenzyl phthalate
Definition: A benzyl ester that has formula C19H20O4.
Chemical ID: MESH:C027561
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISOEsr1 (Mus musculus)6480464CTDbutylbenzyl phthalate binds to ESR1 proteinPMID:19913605
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTDbutylbenzyl phthalate binds to ESR1 proteinPMID:19913605 PMID:20822795 PMID:22467034
Esr1decreases expressionISOESR1 (Homo sapiens)6480464CTDbutylbenzyl phthalate results in decreased expression of ESR1 mRNA; butylbenzyl phthalate results in decreased expression of ESR1 proteinPMID:30851587
Esr1decreases methylationISOESR1 (Homo sapiens)6480464CTDbutylbenzyl phthalate results in decreased methylation of ESR1 gene; butylbenzyl phthalate results in decreased methylation of ESR1 promoterPMID:16326419 PMID:22949852
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDbutylbenzyl phthalate results in increased activity of ESR1 proteinPMID:28571686
Esr1multiple interactionsISOEsr1 (Mus musculus)6480464CTD[diethyl phthalate co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with diisononyl phthalate co-treated with diisobutyl phthalate co-treated with butylbenzyl phthalate] results in decreased expression of ESR1 mRNAPMID:28013214
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTDbutylbenzyl phthalate binds to and results in increased activity of ESR1 protein; butylbenzyl phthalate inhibits the reaction [Estradiol results in increased activity of ESR1 protein]; Oxygen deficiency promotes the reaction [butylbenzyl phthalate results in decreased expression of ESR1 mRNA]; Oxygen deficiency promotes the reaction [butylbenzyl phthalate results in decreased expression of ESR1 protein]; Tamoxifen inhibits the reaction [butylbenzyl phthalate binds to and results in increased activity of ESR1 protein]PMID:15840436 PMID:28571686 PMID:29162470 PMID:30851587 PMID:33049310
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