GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Esr1 | affects binding | EXP | | 6480464 | CTD | daidzein binds to ESR1 protein | PMID:19913605 | Esr1 | affects response to substance | EXP | | 6480464 | CTD | ESR1 protein affects the susceptibility to daidzein | PMID:19400946 | Esr1 | affects binding | ISO | Esr1 (Mus musculus) | 6480464 | CTD | daidzein binds to ESR1 protein | PMID:19913605 | Esr1 | affects binding | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | daidzein binds to ESR1 protein | PMID:12598185 PMID:14579009 PMID:16506809 PMID:16773531 PMID:18692112 PMID:19913605 | Esr1 | decreases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | daidzein results in decreased expression of ESR1 mRNA; daidzein results in decreased expression of ESR1 protein | PMID:16033089 | Esr1 | increases activity | ISO | Esr1 (Mus musculus) | 6480464 | CTD | daidzein results in increased activity of ESR1 protein | PMID:19495926 | Esr1 | increases activity | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | daidzein results in increased activity of ESR1 protein | PMID:16118406 PMID:19161236 PMID:24284790 | Esr1 | increases expression | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | daidzein results in increased expression of ESR1 mRNA; daidzein results in increased expression of ESR1 protein | PMID:27576059 | Esr1 | multiple interactions | ISO | ESR1 (Homo sapiens) | 6480464 | CTD | [daidzein binds to ESR1 protein] which results in increased activity of ALPL protein; [daidzein co-treated with ESR1 protein] results in decreased expression of EGFR mRNA; [daidzein co-treated with ESR1 protein] results in decreased expression of EGFR protein; [daidzein co-treated with ESR1 protein] results in increased expression of BGLAP mRNA; [daidzein co-treated with ESR1 protein] results in increased expression of BSP mRNA; daidzein binds to and results in increased activity of ESR1 protein; daidzein inhibits the reaction [bisphenol A results in decreased expression of ESR1 mRNA]; daidzein inhibits the reaction [Estradiol binds to ESR1 protein]; daidzein metabolite binds to and results in increased activity of ESR1 protein; daidzein metabolite promotes the reaction [NCOA2 protein binds to ESR1 protein]; daidzein promotes the reaction [Estradiol results in increased activity of ESR1 protein]; ESR1 protein affects the reaction [daidzein results in decreased expression of IL6 mRNA]; ESR1 protein affects the reaction [daidzein results in decreased secretion of IL6 protein]; ESR1 protein inhibits the reaction [daidzein results in increased expression of CXCL12 mRNA]; ESR1 protein inhibits the reaction [daidzein results in increased expression of GREB1 mRNA]; ESR1 protein inhibits the reaction [daidzein results in increased expression of PGR mRNA]; ESR1 protein inhibits the reaction [daidzein results in increased expression of PRSS23 mRNA]; ESR1 protein inhibits the reaction [daidzein results in increased expression of TFF1 mRNA]; Estradiol affects the reaction [daidzein metabolite affects the activity of ESR1 protein]; Fulvestrant inhibits the reaction [[daidzein binds to ESR1 protein] which results in increased activity of ALPL protein] | PMID:12650720 PMID:14579009 PMID:15084758 PMID:15876408 PMID:16076101 PMID:16118406 PMID:16965913 PMID:19347870 PMID:23384675 PMID:25012808 PMID:27576059 PMID:29162470 PMID:32963737 PMID:33049310 PMID:9751507 | | ||||||||||||||||||||||
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