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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1increases expressionISOEsr1 (Mus musculus)6480464CTDLipopolysaccharides results in increased expression of ESR1 mRNAPMID:12057914
Esr1multiple interactionsISOEsr1 (Mus musculus)6480464CTD[Lipopolysaccharides co-treated with formononetin] results in increased expression of ESR1 protein; [notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein; ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of GUCY1A1 mRNA]; ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of GUCY1A1 protein]; ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of GUCY1B1 mRNA]; ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of GUCY1B1 protein]; ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of NOS3 mRNA]; ESR1 protein affects the reaction [Lipopolysaccharides affects the expression of NOS3 protein]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Nitroprusside]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Acetylcholine]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine co-treated with Nitroprusside]; ESR1 protein affects the susceptibility to [Lipopolysaccharides co-treated with Phenylephrine]; Fulvestrant inhibits the reaction [[notoginsenoside R1 co-treated with Lipopolysaccharides] results in increased expression of ESR1 protein]PMID:17158209 PMID:23170834 PMID:37269934
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