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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2557
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ephx1
Name: epoxide hydrolase 1
Acc ID: CHEBI:28077
Term: rifampicin
Definition: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei).
Chemical ID: MESH:D012293
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ephx1increases expressionISOEPHX1 (Homo sapiens)6480464CTDRifampin results in increased expression of EPHX1 mRNAPMID:22258563 PMID:25313206 PMID:29356861
Ephx1multiple interactionsISOEPHX1 (Homo sapiens)6480464CTDpimecrolimus inhibits the reaction [Rifampin results in increased expression of EPHX1 mRNA]PMID:29356861
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