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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2546
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egr4
Name: early growth response 4
Acc ID: CHEBI:17303
Term: morphine
Definition: A morphinane alkaloid that is a highly potent opiate analgesic psychoactive drug. Morphine acts directly on the central nervous system (CNS) to relieve pain but has a high potential for addiction, with tolerance and both physical and psychological dependence developing rapidly. Morphine is the most abundant opiate found in Papaver somniferum (the opium poppy).
Chemical ID: MESH:D009020
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDMorphine results in increased expression of EGR4 mRNA

PMID:22454534
multiple interactionsEXP 6480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3, 4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA]

PMID:22454534
affects response to substanceISORGD:7358186480464CTDEGR4 protein affects the susceptibility to Morphine

PMID:22454534
increases expressionISORGD:7358186480464CTDMorphine results in increased expression of EGR4 mRNA

PMID:22454534
multiple interactionsISORGD:7358186480464CTD2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3, 4-difluorobenzamide inhibits the reaction [Morphine results in increased expression of EGR4 mRNA], [Morphine results in increased activity of ELK1 protein] which results in increased expression of EGR4 mRNA

PMID:22454534
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.