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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:31941
Term: oxaliplatin
Definition: A platinum coordination entity that is a commonly used chemothrepeutic drug for treatment of colorectal cancer.
Chemical ID: MESH:C030110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrmultiple interactionsEXP 6480464CTD[oxaliplatin co-treated with Topotecan] results in increased expression of EGFR mRNAPMID:25729387
Egfrincreases phosphorylationISOEGFR (Homo sapiens)6480464CTDoxaliplatin results in increased phosphorylation of EGFR proteinPMID:16243822
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTD[gefitinib co-treated with oxaliplatin] results in decreased phosphorylation of EGFR protein; EGFR gene polymorphism affects the susceptibility to [oxaliplatin co-treated with Fluorouracil]PMID:13680161 PMID:16098254
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