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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2543
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egfr
Name: epidermal growth factor receptor
Acc ID: CHEBI:3087
Term: betulinic acid
Definition: A pentacyclic triterpenoid that is lupane having a double bond at position 20(29) as well as 3beta-hydroxy and 28-carboxy substituents. It is found in the bark and other plant parts of several species of plants including Syzygium claviflorum. It exhibits anti-HIV, antimalarial, antineoplastic and anti-inflammatory properties.
Chemical ID: MESH:C002070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfrincreases phosphorylationISOEGFR (Homo sapiens)6480464CTDBetulinic Acid results in increased phosphorylation of EGFR proteinPMID:16077934
Egfrmultiple interactionsISOEGFR (Homo sapiens)6480464CTD4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline inhibits the reaction [Betulinic Acid results in increased phosphorylation of EGFR protein]; Betulinic Acid promotes the reaction [Gefitinib results in decreased expression of EGFR protein modified form]PMID:16077934 PMID:30136359
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