GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Egfr | increases phosphorylation | EXP | | 6480464 | CTD | Acrolein results in increased phosphorylation of EGFR protein | PMID:20359552 | Egfr | multiple interactions | EXP | | 6480464 | CTD | Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein]]; Simvastatin inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein] | PMID:20359552 | Egfr | increases activity | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Acrolein results in increased activity of EGFR protein | PMID:11329622 | Egfr | increases phosphorylation | ISO | Egfr (Mus musculus) | 6480464 | CTD | Acrolein results in increased phosphorylation of EGFR protein | PMID:20153347 | Egfr | increases phosphorylation | ISO | EGFR (Homo sapiens) | 6480464 | CTD | Acrolein results in increased phosphorylation of EGFR protein | PMID:11329622 PMID:15531749 | Egfr | multiple interactions | ISO | EGFR (Homo sapiens) | 6480464 | CTD | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased expression of EGFR mRNA; [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased expression of EGFR mRNA; EGFR protein affects the reaction [Acrolein results in increased expression of MUC5AC mRNA]; RTKI cpd inhibits the reaction [Acrolein results in increased phosphorylation of EGFR protein] | PMID:15531749 PMID:32699268 | | ||||||||||||||||||||||
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