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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2542
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Egf
Name: epidermal growth factor
Acc ID: CHEBI:30050
Term: gold(0)
Definition: An elemental gold that has formula Au.
Chemical ID: MESH:D006046
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Egfmultiple interactionsISOEGF (Homo sapiens)6480464CTD[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]PMID:27634460
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