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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:4042
Term: cypermethrin
Definition: A carboxylic ester resulting from the formal condensation between 3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid and the alcoholic hydroxy group of hydroxy(3-phenoxyphenyl)acetonitrile.
Chemical ID: MESH:C017160
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2decreases expressionEXP 6480464CTDcypermethrin results in decreased expression of DRD2 mRNA; cypermethrin results in decreased expression of DRD2 proteinPMID:25288152
Drd2multiple interactionsEXP 6480464CTDcypermethrin inhibits the reaction [[Quinpirole binds to and results in increased activity of DRD2 protein] which results in increased uptake of Dopamine]; cypermethrin promotes the reaction [cypermethrin results in decreased expression of DRD2 mRNA]; cypermethrin promotes the reaction [cypermethrin results in decreased expression of DRD2 protein]PMID:10936494 PMID:25288152
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