GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Drd2 | affects binding | EXP | | 6480464 | CTD | Clozapine analog binds to DRD2 protein; Clozapine binds to DRD2 protein | PMID:11997696 PMID:9723970 | Drd2 | affects response to substance | EXP | | 6480464 | CTD | DRD2 protein affects the susceptibility to Clozapine | PMID:11997696 | Drd2 | decreases expression | EXP | | 6480464 | CTD | Clozapine results in decreased expression of DRD2 mRNA | PMID:15781964 | Drd2 | multiple interactions | EXP | | 6480464 | CTD | [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein; Bromocriptine promotes the reaction [Clozapine results in decreased expression of DRD2 mRNA]; Clozapine binds to and results in decreased activity of DRD2 protein; Clozapine promotes the reaction [Dopamine binds to DRD2 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of CTNNB1 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of DVL3 protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3A protein]; DRD2 protein affects the reaction [Clozapine results in increased expression of GSK3B protein] | PMID:15716360 PMID:15781964 PMID:16033416 PMID:16144542 | Drd2 | affects binding | ISO | Drd2 (Mus musculus) | 6480464 | CTD | Clozapine binds to DRD2 protein alternative form | PMID:12476322 | Drd2 | affects binding | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | Clozapine binds to DRD2 protein | PMID:11997696 PMID:1352677 | Drd2 | affects response to substance | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | DRD2 gene affects the susceptibility to Clozapine; DRD2 gene polymorphism affects the susceptibility to Clozapine | PMID:15830237 PMID:16278074 | Drd2 | decreases expression | ISO | Drd2 (Mus musculus) | 6480464 | CTD | Clozapine results in decreased expression of DRD2 mRNA | PMID:17266109 | Drd2 | increases response to substance | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | DRD2 gene SNP results in increased susceptibility to Clozapine | PMID:20375926 | Drd2 | multiple interactions | ISO | Drd2 (Mus musculus) | 6480464 | CTD | [Clozapine co-treated with Bromocriptine] results in decreased expression of DRD2 mRNA | PMID:15781964 | Drd2 | multiple interactions | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | [Clozapine co-treated with DRD2 gene polymorphism] results in increased secretion of PRL protein | PMID:15286066 | |
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