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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:31515
Term: domperidone
Definition: 1-[3-(Piperidin-1-yl)propyl]-1,3-dihydro-2H-benzimidazol-2-one in which the 4-position of the piperidine ring is substituted by a 5-chloro-1,3-dihydro-2H-benzimidazol-2-on-1-yl group. A dopamine antagonist, it is used as an antiemetic for the short-term treatment of nausea and vomiting, and to control gastrointestinal effects of dopaminergic drugs given in the management of parkinsonism. The free base is used in oral suspensions, while the maleate salt is used in tablet preparations.
Chemical ID: MESH:D004294
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects bindingEXP 6480464CTDDomperidone binds to DRD2 proteinPMID:12130853
Drd2multiple interactionsEXP 6480464CTDDomperidone binds to and results in decreased activity of DRD2 proteinPMID:10626749 PMID:12071432 PMID:2571179 PMID:8103596
Drd2affects bindingISODrd2 (Mus musculus)6480464CTDDomperidone binds to DRD2 proteinPMID:12673668
Drd2multiple interactionsISODrd2 (Mus musculus)6480464CTDCyclosporine promotes the reaction [Domperidone binds to DRD2 protein]PMID:12673668
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