GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Drd2 | affects expression | EXP | | 6480464 | CTD | Cocaine affects the expression of DRD2; Cocaine affects the expression of DRD2 mRNA; Cocaine affects the expression of DRD2 protein | PMID:12892653 PMID:17544385 PMID:18990547 PMID:20435100 | Drd2 | affects response to substance | EXP | | 6480464 | CTD | DRD2 protein affects the susceptibility to Cocaine | PMID:2213551 | Drd2 | decreases expression | EXP | | 6480464 | CTD | Cocaine results in decreased expression of DRD2 mRNA; Cocaine results in decreased expression of DRD2 protein | PMID:18305460 | Drd2 | increases activity | EXP | | 6480464 | CTD | Cocaine results in increased activity of DRD2 protein | PMID:19046384 | Drd2 | increases expression | EXP | | 6480464 | CTD | Cocaine results in increased expression of DRD2 mRNA; Cocaine results in increased expression of DRD2 protein | PMID:11602327 PMID:15042275 PMID:15049517 | Drd2 | multiple interactions | EXP | | 6480464 | CTD | Cocaine affects the reaction [Spiperone binds to DRD2 protein]; Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]; Methadone affects the reaction [Cocaine affects the expression of DRD2 mRNA]; Spiperone inhibits the reaction [Cocaine promotes the reaction [[DRD2 protein results in increased phosphorylation of TH protein] which results in increased abundance of Dopamine]] | PMID:17161392 PMID:18990547 PMID:20729865 | Drd2 | decreases expression | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | Cocaine results in decreased expression of DRD2 mRNA; Cocaine results in decreased expression of DRD2 protein | PMID:11126397 PMID:18000554 PMID:19723785 PMID:9892293 | Drd2 | decreases response to substance | ISO | Drd2 (Mus musculus) | 6480464 | CTD | DRD2 protein results in decreased susceptibility to Cocaine | PMID:11923462 | Drd2 | increases expression | ISO | Drd2 (Mus musculus) | 6480464 | CTD | Cocaine deficiency results in increased expression of DRD2 mRNA; Cocaine results in increased expression of DRD2 protein | PMID:27126842 PMID:35597300 | Drd2 | increases response to substance | ISO | Drd2 (Mus musculus) | 6480464 | CTD | DRD2 results in increased susceptibility to Cocaine | PMID:11790512 | Drd2 | increases response to substance | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | DRD2 polymorphism results in increased susceptibility to Cocaine | PMID:17671965 | Drd2 | multiple interactions | ISO | Drd2 (Mus musculus) | 6480464 | CTD | PDYN protein affects the reaction [Cocaine affects the expression of DRD2 protein] | PMID:17532787 | Drd2 | multiple interactions | ISO | DRD2 (Homo sapiens) | 6480464 | CTD | Cocaine affects the reaction [Raclopride binds to DRD2] | PMID:15010698 | |
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