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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2520
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Drd2
Name: dopamine receptor D2
Acc ID: CHEBI:107736
Term: metoclopramide
Definition: A member of the class of benzamides resulting from the formal condensation of 4-amino-5-chloro-2-methoxybenzoic acid with the primary amino group of N,N-diethylethane-1,2-diamine.
Chemical ID: MESH:D008787
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Drd2affects bindingEXP 6480464CTDMetoclopramide binds to DRD2 proteinPMID:12130853 PMID:12593651
Drd2increases expressionEXP 6480464CTDMetoclopramide results in increased expression of DRD2 proteinPMID:18457824
Drd2multiple interactionsEXP 6480464CTDMetoclopramide binds to and results in decreased activity of DRD2 proteinPMID:17201744 PMID:17303669 PMID:18457824 PMID:1930352
Drd2affects bindingISODrd2 (Mus musculus)6480464CTDMetoclopramide binds to DRD2 proteinPMID:9808703
Drd2multiple interactionsISODRD2 (Homo sapiens)6480464CTDMetoclopramide binds to and results in decreased activity of DRD2 proteinPMID:11561213 PMID:21175574
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