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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:52392
Term: 2-arachidonoylglycerol
Definition: An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.
Chemical ID: MESH:C094503
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:104586480464CTDglyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA

PMID:23894352
increases expressionISORGD:692106480464CTDglyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA

PMID:23894352
multiple interactionsISORGD:104586480464CTDCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]

PMID:23894352
multiple interactionsISORGD:692106480464CTDCNR1 gene mutant form inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA], glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter], INS protein inhibits the reaction [glyceryl 2-arachidonate promotes the reaction [CREB3L3 protein binds to CYP7A1 promoter]], INS protein inhibits the reaction [glyceryl 2-arachidonate results in increased expression of CYP7A1 mRNA]

PMID:23894352
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.