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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:34873
Term: N-nitrosodiethylamine
Definition: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom.
Chemical ID: MESH:D004052
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp7a1decreases expressionEXP 6480464CTDDiethylnitrosamine results in decreased expression of CYP7A1 mRNAPMID:19638242
Cyp7a1multiple interactionsEXP 6480464CTD[2-Acetylaminofluorene co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of CYP7A1 mRNA; [Fenofibrate co-treated with Diethylnitrosamine] results in decreased expression of CYP7A1 mRNAPMID:14656948 PMID:16158176 PMID:18253720
Cyp7a1increases expressionISOCyp7a1 (Mus musculus)6480464CTDDiethylnitrosamine results in increased expression of CYP7A1 mRNAPMID:18691550
Cyp7a1multiple interactionsISOCyp7a1 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with kojic acid] results in increased expression of CYP7A1 mRNA; [Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CYP7A1 mRNA; IKBKB protein inhibits the reaction [Diethylnitrosamine results in increased expression of CYP7A1 mRNA]PMID:17917374 PMID:18691550 PMID:24535843
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