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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2482
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp7a1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:16755
Term: chenodeoxycholic acid
Definition: A dihydroxy-5beta-cholanic acid that is (5beta)-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 7 respectively.
Chemical ID: MESH:D002635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTD[Chenodeoxycholic Acid co-treated with Ketoconazole] results in decreased expression of CYP7A1 mRNA, [Chenodeoxycholic Acid results in increased expression of FGF19 protein] which results in decreased expression of CYP7A1 protein

PMID:20835427, PMID:30985903
decreases expressionISORGD:104586480464CTDChenodeoxycholic Acid results in decreased expression of CYP7A1 mRNA

PMID:19072826, PMID:20671298, PMID:25582706
decreases expressionISORGD:692106480464CTDChenodeoxycholic Acid results in decreased expression of CYP7A1 mRNA

PMID:19072826, PMID:25055961, PMID:27174168
multiple interactionsISORGD:104586480464CTDNR1H4 mutant form inhibits the reaction [Chenodeoxycholic Acid results in decreased expression of CYP7A1 mRNA]

PMID:19072826
multiple interactionsISORGD:692106480464CTD[Chenodeoxycholic Acid analog binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA, [Chenodeoxycholic Acid binds to and results in increased activity of NR1H4 protein] which results in decreased expression of CYP7A1 mRNA

PMID:17963371
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.