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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2476
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2f4
Name: cytochrome P450, family 2, subfamily f, polypeptide 4
Acc ID: CHEBI:46195
Term: paracetamol
Definition: A member of the class of phenols that is 4-aminophenol in which one of the hydrogens attached to the amino group has been replaced by an acetyl group.
Chemical ID: MESH:D000082
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2f4affects expressionISOCyp2f2 (Mus musculus)6480464CTDAcetaminophen affects the expression of CYP2F2 mRNAPMID:17562736
Cyp2f4decreases expressionISOCyp2f2 (Mus musculus)6480464CTDAcetaminophen results in decreased expression of CYP2F2 mRNAPMID:29246445
Cyp2f4multiple interactionsISOCyp2f2 (Mus musculus)6480464CTD[Clofibrate co-treated with Acetaminophen] affects the expression of CYP2F2 mRNA; PANX1 gene mutant form inhibits the reaction [Acetaminophen results in decreased expression of CYP2F2 mRNA]; PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of CYP2F2 mRNA]PMID:17585979 PMID:29246445
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