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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:39827
Term: fumaraldehyde
Definition: A but-2-enedial that has formula 84.07336.
Chemical ID: MESH:C015977
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1multiple interactionsEXP 6480464CTD1-phenylimidazole inhibits the reaction [[[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde]; [[[CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehyde] which co-treated with Glutathione] results in increased glutathionylation of malealdehyde; [CYP2E1 protein results in increased oxidation of furan] which results in increased chemical synthesis of malealdehydePMID:21842885
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