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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:28946
Term: theobromine
Definition: A dimethylxanthine having the two methyl groups located at positions 3 and 7. A purine alkaloid derived from the cacao plant, it is found in chocolate, as well as in a number of other foods, and is a vasodilator, diuretic and heart stimulator.
Chemical ID: MESH:D013805
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases chemical synthesisISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased chemical synthesis of TheobrominePMID:1302044
Cyp2e1increases metabolic processingISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein results in increased metabolism of TheobrominePMID:10215755
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTD4-nitrophenol inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine]; Ditiocarb inhibits the reaction [CYP2E1 protein results in increased metabolism of Theobromine]PMID:10215755
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