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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1multiple interactionsEXP 6480464CTDQuercetin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine]; Quercetin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]; Quercetin promotes the reaction [Dexamethasone results in increased expression of CYP2E1 mRNA]; Quercetin promotes the reaction [Dexamethasone results in increased expression of CYP2E1 protein]PMID:11306697 PMID:20501703 PMID:7710944
Cyp2e1decreases activityISOCyp2e1 (Mus musculus)6480464CTDQuercetin results in decreased activity of CYP2E1 proteinPMID:18420780
Cyp2e1decreases activityISOCYP2E1 (Homo sapiens)6480464CTDQuercetin results in decreased activity of CYP2E1 proteinPMID:28232125 PMID:29753067
Cyp2e1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTDQuercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of CYP2E1 protein]PMID:26218279
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTDQuercetin inhibits the reaction [[CYP2E1 protein results in increased susceptibility to Docosahexaenoic Acids] which results in increased phosphorylation of MAP2K4 protein]; Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]; zinc protoporphyrin inhibits the reaction [Quercetin inhibits the reaction [Ethanol results in increased expression of and results in increased activity of CYP2E1 protein]]PMID:16963249 PMID:19325051
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