Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2475
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2e1
Name: cytochrome P450, family 2, subfamily e, polypeptide 1
Acc ID: CHEBI:16227
Term: pyridine
Definition: An azaarene comprising a benzene core in which one -CH group is replaced by a nitrogen atom. It is the parent compound of the class pyridines.
Chemical ID: MESH:C023666
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2e1increases activityEXP 6480464CTDpyridine results in increased activity of CYP2E1 proteinPMID:11181506 PMID:12919724 PMID:1610360 PMID:1968335 PMID:23211455 PMID:8246169 PMID:8734847 PMID:9618253
Cyp2e1increases expressionEXP 6480464CTDpyridine results in increased expression of CYP2E1 mRNA; pyridine results in increased expression of CYP2E1 proteinPMID:10215695 PMID:11181506 PMID:12919724 PMID:1379807 PMID:1610360 PMID:1968335 PMID:2241968 PMID:7587954 PMID:8246169 PMID:8734847 PMID:9618253
Cyp2e1multiple interactionsEXP 6480464CTD[pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 mRNA; [pyridine co-treated with Methylcholanthrene] results in decreased expression of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased activity of CYP2E1 protein; [pyridine co-treated with Methylcholanthrene] results in increased expression of CYP2E1 protein; Cycloheximide inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]; Cycloheximide inhibits the reaction [pyridine results in increased expression of CYP2E1 protein]; Ditiocarb inhibits the reaction [pyridine results in increased activity of CYP2E1 protein]; INS protein affects the reaction [pyridine results in increased expression of CYP2E1 protein]; pyridine promotes the reaction [ciprofibrate results in increased expression of CYP2E1 protein]; pyridine promotes the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]PMID:10215695 PMID:1968335 PMID:7587954 PMID:8734847 PMID:9618253
Cyp2e1decreases activityISOCYP2E1 (Homo sapiens)6480464CTDpyridine results in decreased activity of CYP2E1 proteinPMID:12464242
Cyp2e1increases expressionISOCYP2E1 (Homo sapiens)6480464CTDpyridine results in increased expression of CYP2E1 proteinPMID:8074729
Cyp2e1multiple interactionsISOCYP2E1 (Homo sapiens)6480464CTDCYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]; Dimethyl Sulfoxide inhibits the reaction [CYP2E1 protein promotes the reaction [pyridine results in increased expression of CYP1A1 mRNA]]PMID:12147272
Go Back to source page   Continue to Ontology report