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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2466
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2b1
Name: cytochrome P450, family 2, subfamily b, polypeptide 1
Acc ID: CHEBI:34911
Term: permethrin
Definition: A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups.
Chemical ID: MESH:D026023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp2b1increases expressionEXP 6480464CTDPermethrin results in increased expression of CYP2B1 mRNAPMID:11377398 PMID:14722249
Cyp2b1multiple interactionsEXP 6480464CTD[Permethrin co-treated with DEET] results in increased methylation of CYP2B1 gene; [Permethrin co-treated with Piperonyl Butoxide] results in increased expression of CYP2B1 mRNA; EGF protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA]; GH1 protein inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA]; Piperonyl Butoxide inhibits the reaction [Permethrin results in increased expression of CYP2B1 mRNA]PMID:11377398 PMID:14722249 PMID:33148267
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