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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2462
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp24a1
Name: cytochrome P450, family 24, subfamily a, polypeptide 1
Acc ID: CHEBI:31186
Term: alfacalcidol
Definition: A member of the class of D3 vitamins that is calciol in which the hydrogen at the 1alpha position is replaced by a hydroxy group. It is an active metabolite of cholecalciferol, which performs important functions in regulation of the calcium balance and the bone metabolism.
Chemical ID: MESH:C008088
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp24a1increases expressionEXP 6480464CTDalfacalcidol results in increased expression of CYP24A1 mRNA; alfacalcidol results in increased expression of CYP24A1 proteinPMID:8410379
Cyp24a1increases expressionISOCYP24A1 (Homo sapiens)6480464CTDalfacalcidol results in increased expression of CYP24A1 mRNAPMID:16824767
Cyp24a1increases expressionISOCyp24a1 (Mus musculus)6480464CTDalfacalcidol results in increased expression of CYP24A1 mRNAPMID:18180267 PMID:19581390
Cyp24a1multiple interactionsISOCYP24A1 (Homo sapiens)6480464CTD[Ketoconazole results in decreased metabolism of alfacalcidol] which results in decreased expression of CYP24A1 mRNAPMID:16824767
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