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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:16243
Term: quercetin
Definition: A pentahydroxyflavone having the five hydroxy groups placed at the 3-, 3'-, 4'-, 5- and 7-positions. It is one of the most abundant flavonoids in edible vegetables, fruit and wine.
Chemical ID: MESH:D011794
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1affects expressionEXP 6480464CTDQuercetin affects the expression of CYP1B1 mRNAPMID:18178720
Cyp1b1decreases activityISOCyp1b1 (Mus musculus)6480464CTDQuercetin results in decreased activity of CYP1B1 proteinPMID:18420780
Cyp1b1decreases activityISOCYP1B1 (Homo sapiens)6480464CTDQuercetin results in decreased activity of CYP1B1 proteinPMID:16271822 PMID:21482471
Cyp1b1decreases expressionISOCYP1B1 (Homo sapiens)6480464CTDQuercetin results in decreased expression of CYP1B1 mRNAPMID:17637178
Cyp1b1increases expressionISOCyp1b1 (Mus musculus)6480464CTDQuercetin results in increased expression of CYP1B1 mRNAPMID:22334599
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDQuercetin results in increased expression of CYP1B1 mRNAPMID:19794518 PMID:21256954 PMID:21756928
Cyp1b1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTD[Quercetin co-treated with Oxygen] results in increased expression of CYP1B1 mRNAPMID:29432836
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTDQuercetin binds to and results in decreased activity of CYP1B1 proteinPMID:21053930
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