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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2460
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1b1
Name: cytochrome P450, family 1, subfamily b, polypeptide 1
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1b1decreases activityISOCyp1b1 (Mus musculus)6480464CTDTretinoin results in decreased activity of CYP1B1 proteinPMID:18420780
Cyp1b1increases expressionISOCYP1B1 (Homo sapiens)6480464CTDTretinoin results in increased expression of CYP1B1 mRNAPMID:12870655 PMID:16985168 PMID:21934132
Cyp1b1multiple interactionsISOCyp1b1 (Mus musculus)6480464CTD[bisphenol A co-treated with Tretinoin] results in decreased expression of CYP1B1 mRNA; [bisphenol F co-treated with Tretinoin] results in decreased expression of CYP1B1 mRNA; [bisphenol S co-treated with Tretinoin] results in decreased expression of CYP1B1 mRNAPMID:30951980
Cyp1b1multiple interactionsISOCYP1B1 (Homo sapiens)6480464CTD[Tretinoin co-treated with arsenic trioxide] results in decreased expression of CYP1B1 mRNA; [Tretinoin co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1B1 mRNA; Tretinoin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]PMID:15075337 PMID:15894607 PMID:21376804
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