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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2459
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a2
Name: cytochrome P450, family 1, subfamily a, polypeptide 2
Acc ID: CHEBI:47519
Term: ketoconazole
Definition: A racemate consisting of equimolar amounts of (2R,4S)- and (2S,4R)-ketoconazole.
Chemical ID: MESH:D007654
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a2decreases activityEXP 6480464CTDKetoconazole results in decreased activity of CYP1A2 proteinPMID:12814958 PMID:15879494
Cyp1a2multiple interactionsEXP 6480464CTDKetoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of 3-cyano-7-ethoxycoumarin]PMID:19858067
Cyp1a2decreases activityISOCyp1a2 (Mus musculus)6480464CTDKetoconazole results in decreased activity of CYP1A2 proteinPMID:18420780
Cyp1a2decreases activityISOCYP1A2 (Homo sapiens)6480464CTDKetoconazole results in decreased activity of CYP1A2 proteinPMID:15618748 PMID:15916432
Cyp1a2increases expressionISOCYP1A2 (Homo sapiens)6480464CTDKetoconazole results in increased expression of CYP1A2 mRNA; Ketoconazole results in increased expression of CYP1A2 proteinPMID:25000292
Cyp1a2multiple interactionsISOCyp1a2 (Mus musculus)6480464CTDKetoconazole inhibits the reaction [CYP1A2 protein results in increased oxidation of Uroporphyrinogens]PMID:1567206
Cyp1a2multiple interactionsISOCYP1A2 (Homo sapiens)6480464CTDKetoconazole affects the reaction [[NADP co-treated with CYP1A2 protein co-treated with CYP2C8 protein co-treated with CYP2C9 protein co-treated with CYP2C19 protein co-treated with CYP2D6 protein co-treated with CYP3A4 protein co-treated with POR protein] results in increased metabolism of 1-(3-(4-phenoxyphenoxy)-2-oxopropyl)indole-5-carboxylic acid]; Ketoconazole inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]PMID:24120545 PMID:9305587
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