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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:82436
Term: decabromodiphenyl ether
Definition: A polybromodiphenyl ether that is diphenyl ether in which all of the hydrogens have been replaced by bromines.
Chemical ID: MESH:C010902
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases activityEXP 6480464CTDdecabromobiphenyl ether results in increased activity of CYP1A1 proteinPMID:18495385
Cyp1a1increases expressionEXP 6480464CTDdecabromobiphenyl ether results in increased expression of CYP1A1 mRNAPMID:23914054 PMID:32679240
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDdecabromobiphenyl ether results in increased expression of CYP1A1 mRNA; decabromobiphenyl ether results in increased expression of CYP1A1 proteinPMID:31326446 PMID:34571075 PMID:35266255
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [decabromobiphenyl ether results in increased expression of CYP1A1 protein]PMID:34571075
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