GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | increases activity | EXP | | 6480464 | CTD | chrysene results in increased activity of CYP1A1 protein | PMID:10190573 PMID:16906435 | Cyp1a1 | increases expression | EXP | | 6480464 | CTD | chrysene results in increased expression of CYP1A1 mRNA | PMID:17961608 | Cyp1a1 | multiple interactions | EXP | | 6480464 | CTD | [chrysene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [chrysene co-treated with benz(a)anthracene] promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; [chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene] results in increased expression of CYP1A1 mRNA; [chrysene co-treated with Benzo(a)pyrene co-treated with benz(a)anthracene] results in increased expression of CYP1A1 mRNA; [chrysene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 mRNA; chrysene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] | PMID:15315710 PMID:37189300 | Cyp1a1 | decreases expression | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | chrysene results in decreased expression of CYP1A1 mRNA | PMID:26377693 | Cyp1a1 | increases expression | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | chrysene results in increased expression of CYP1A1 mRNA; chrysene results in increased expression of CYP1A1 protein | PMID:12117779 PMID:17156822 PMID:22120587 PMID:26377693 | Cyp1a1 | increases expression | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | chrysene results in increased expression of CYP1A1 mRNA; chrysene results in increased expression of CYP1A1 protein | PMID:12107646 PMID:15566942 PMID:17253728 PMID:21781905 PMID:27196671 PMID:31087746 | Cyp1a1 | multiple interactions | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | [Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of CYP1A1 mRNA; [CYP1A1 protein co-treated with Trichloroepoxypropane] results in increased metabolism of chrysene; [fluoranthene co-treated with pyrene co-treated with benz(a)anthracene co-treated with chrysene co-treated with benzo(b)fluoranthene co-treated with benzo(k)fluoranthene co-treated with Benzo(a)pyrene] results in increased expression of CYP1A1 mRNA; EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of chrysene] | PMID:27858113 PMID:7750161 PMID:8961944 | Cyp1a1 | multiple interactions | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | [chrysene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA; [CYP1A1 protein co-treated with Trichloroepoxypropane] results in increased metabolism of chrysene; alpha-naphthoflavone inhibits the reaction [[chrysene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; chrysene promotes the reaction [AHR protein results in increased expression of CYP1A1 mRNA]; EPHX1 protein promotes the reaction [CYP1A1 protein results in increased metabolism of chrysene] | PMID:12799773 PMID:21781905 PMID:8961944 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |