GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | decreases expression | EXP | | 6480464 | CTD | Cacodylic Acid results in decreased expression of CYP1A1 mRNA | PMID:37567419 | Cyp1a1 | increases expression | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | Cacodylic Acid results in increased expression of CYP1A1 mRNA | PMID:24161444 | Cyp1a1 | multiple interactions | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | [sodium arsenate co-treated with sodium arsenite co-treated with monomethylarsonic acid co-treated with Cacodylic Acid] results in decreased expression of CYP1A1 mRNA; Cacodylic Acid affects the reaction [[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; Cacodylic Acid affects the reaction [[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein] | PMID:28134025 PMID:34876320 | Cyp1a1 | multiple interactions | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | AHR mutant form inhibits the reaction [Cacodylic Acid results in increased expression of CYP1A1 protein]; Cacodylic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of and results in increased activity of CYP1A1 protein]; Cacodylic Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Cacodylic Acid results in increased expression of and results in increased activity of CYP1A1 protein | PMID:24161444 | | ||||||||||||||||||||||
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