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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:43645
Term: indirubin-3'-monoxime
Definition: A member of the class of biindoles that is indirubin in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime.
Chemical ID: MESH:C474021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionEXP 6480464CTDindirubin-3'-monoxime results in increased expression of CYP1A1 mRNAPMID:15001395
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDindirubin-3'-monoxime results in increased expression of CYP1A1 proteinPMID:21948866
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDindirubin-3'-monoxime results in increased expression of CYP1A1 mRNAPMID:18958680
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate co-treated with Lipopolysaccharides] results in increased expression of CYP1A1 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP1A1 mRNA; [indirubin-3'-monoxime co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CYP1A1 proteinPMID:18958680
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