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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:34107
Term: 1-nitropyrene
Definition: A nitroarene that is pyrene substituted at the 1-position by a nitro group. A by-product of combustion, it is the predominant nitrated polycyclic aromatic hydrocarbon emitted in a diesel engine.
Chemical ID: MESH:C032668
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1multiple interactionsEXP 6480464CTD1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]PMID:18493746
Cyp1a1increases degradationISOCYP1A1 (Homo sapiens)6480464CTD1-nitropyrene results in increased degradation of CYP1A1 proteinPMID:16280210
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTD1-nitropyrene results in increased expression of CYP1A1 mRNA; 1-nitropyrene results in increased expression of CYP1A1 proteinPMID:12117779 PMID:17240030 PMID:19961161
Cyp1a1increases stabilityISOCyp1a1 (Mus musculus)6480464CTD1-nitropyrene results in increased stability of CYP1A1 mRNAPMID:19961161
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDdeguelin inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]; triciribine inhibits the reaction [1-nitropyrene results in increased stability of CYP1A1 mRNA]PMID:19961161
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 1-nitropyrene inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; 1-nitropyrene inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; CYP1A1 protein affects the susceptibility to [Tetrachlorodibenzodioxin results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]]; Dithiothreitol inhibits the reaction [1-nitropyrene results in increased degradation of CYP1A1 protein]PMID:16280210 PMID:18493746 PMID:22044530
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