GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | increases expression | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | Butyric Acid results in increased expression of CYP1A1 mRNA | PMID:30439556 | Cyp1a1 | multiple interactions | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | Butyric Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] | PMID:31621310 | Cyp1a1 | multiple interactions | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | [Benzo(a)pyrene co-treated with Butyric Acid] results in increased expression of CYP1A1 mRNA; Benzo(a)pyrene promotes the reaction [Butyric Acid results in increased expression of CYP1A1 mRNA]; Butyric Acid inhibits the reaction [HDAC1 protein binds to CYP1A1 enhancer]; Butyric Acid promotes the reaction [[Benzo(a)pyrene results in increased expression of CYP1A1 protein] which results in increased chemical synthesis of benzo(a)pyrene-DNA adduct]; Butyric Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Butyric Acid promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Butyric Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Butyric Acid promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] | PMID:27830268 PMID:30439556 PMID:31621310 PMID:36399157 | | ||||||||||||||||||||||
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