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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:27563
Term: arsenic atom
Definition: A pnictogen that has formula As.
Chemical ID: MESH:D001151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases activityISOCyp1a1 (Mus musculus)6480464CTDArsenic results in increased activity of CYP1A1 proteinPMID:15337587
Cyp1a1increases expressionISOCyp1a1 (Mus musculus)6480464CTDArsenic results in increased expression of CYP1A1 mRNAPMID:15337587
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDArsenic results in increased expression of CYP1A1 mRNAPMID:26988683
Cyp1a1multiple interactionsISOCyp1a1 (Mus musculus)6480464CTDArsenic inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; Arsenic inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Arsenic inhibits the reaction [Methylcholanthrene results in increased activity of CYP1A1 protein]; Arsenic inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; Arsenic promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Arsenic promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; Arsenic promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Arsenic promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Arsenic promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; Arsenic promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 protein]; Arsenic promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Arsenic promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]PMID:15337587
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD[[Industrial Waste results in increased abundance of Trace Elements] which results in increased abundance of Arsenic] which affects the expression of CYP1A1 mRNA; [Benzo(a)pyrene co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of CYP1A1 proteinPMID:32062438 PMID:34083740
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