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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2458
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp1a1
Name: cytochrome P450, family 1, subfamily a, polypeptide 1
Acc ID: CHEBI:16411
Term: indole-3-acetic acid
Definition: A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens has been replaced by a 1H-indol-3-yl group.
Chemical ID: MESH:C030737
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp1a1increases expressionISOCYP1A1 (Homo sapiens)6480464CTDindoleacetic acid results in increased expression of CYP1A1 mRNAPMID:30324315
Cyp1a1multiple interactionsISOCYP1A1 (Homo sapiens)6480464CTD2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [indoleacetic acid results in increased expression of CYP1A1 mRNA]; indoleacetic acid promotes the reaction [AHR protein binds to CYP1A1 promoter]PMID:30324315
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