GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp1a1 | decreases activity | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | Luteolin results in decreased activity of CYP1A1 protein | PMID:21482471 | Cyp1a1 | decreases expression | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | Luteolin results in decreased expression of CYP1A1 protein | PMID:33727136 | Cyp1a1 | increases expression | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | Luteolin results in increased expression of CYP1A1 mRNA | PMID:20930378 | Cyp1a1 | increases expression | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | Luteolin results in increased expression of CYP1A1 mRNA | PMID:20403331 PMID:23994263 PMID:29584932 | Cyp1a1 | increases response to substance | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | CYP1A1 protein results in increased susceptibility to Luteolin | PMID:33727136 | Cyp1a1 | multiple interactions | ISO | Cyp1a1 (Mus musculus) | 6480464 | CTD | Luteolin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA] | PMID:20930378 | Cyp1a1 | multiple interactions | ISO | CYP1A1 (Homo sapiens) | 6480464 | CTD | [CYP1A1 protein results in increased susceptibility to Luteolin] which results in decreased abundance of diosmetin; CYP1A1 protein promotes the reaction [Luteolin results in increased cleavage of CASP3 protein]; CYP1A1 protein promotes the reaction [Luteolin results in increased cleavage of PARP1 protein]; CYP1A1 protein promotes the reaction [Luteolin results in increased expression of H2AX protein]; Luteolin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Dust analog results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Particulate Matter analog results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; Luteolin inhibits the reaction [Vehicle Emissions analog results in increased expression of CYP1A1 mRNA] | PMID:16263508 PMID:17090139 PMID:20403331 PMID:33727136 | |
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