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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2457
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:17574
Term: biochanin A
Definition: A member of the class of 7-hydroxyisoflavones that is 7-hydroxyisoflavone which is substituted by an additional hydroxy group at position 5 and a methoxy group at position 4'. A phytoestrogen, it has putative benefits in dietary cancer prophylaxis.
Chemical ID: MESH:C004541
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1decreases activityISOCYP19A1 (Homo sapiens)6480464CTDbiochanin A results in decreased activity of CYP19A1 proteinPMID:16965912
Cyp19a1decreases expressionISOCYP19A1 (Homo sapiens)6480464CTDbiochanin A results in decreased expression of CYP19A1 mRNAPMID:16965912
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTD[Genistein co-treated with biochanin A co-treated with daidzein] results in decreased activity of CYP19A1 protein; [Genistein co-treated with biochanin A co-treated with daidzein] results in decreased expression of CYP19A1 mRNA; biochanin A binds to and results in decreased activity of CYP19A1 proteinPMID:16965912 PMID:9435150
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