GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cycs | affects localization | EXP | | 6480464 | CTD | Doxorubicin affects the localization of CYCS protein | PMID:16687611 PMID:18845130 PMID:24480152 | Cycs | multiple interactions | EXP | | 6480464 | CTD | pifithrin inhibits the reaction [Doxorubicin affects the localization of CYCS protein] | PMID:16687611 | Cycs | affects expression | ISO | CYCS (Homo sapiens) | 6480464 | CTD | Doxorubicin affects the expression of CYCS mRNA; Doxorubicin affects the expression of CYCS protein | PMID:27780733 PMID:29385562 | Cycs | affects localization | ISO | Cycs (Mus musculus) | 6480464 | CTD | Doxorubicin affects the localization of CYCS protein | PMID:19767621 | Cycs | affects localization | ISO | CYCS (Homo sapiens) | 6480464 | CTD | Doxorubicin affects the localization of CYCS protein | PMID:16749863 PMID:17542780 PMID:21865289 | Cycs | affects response to substance | ISO | CYCS (Homo sapiens) | 6480464 | CTD | CYCS protein affects the susceptibility to Doxorubicin | PMID:16331251 | Cycs | decreases expression | ISO | Cycs (Mus musculus) | 6480464 | CTD | Doxorubicin results in decreased expression of CYCS mRNA | PMID:26873546 | Cycs | increases expression | ISO | CYCS (Homo sapiens) | 6480464 | CTD | Doxorubicin results in increased expression of CYCS mRNA | PMID:16001973 PMID:16705698 PMID:29803840 | Cycs | increases secretion | ISO | Cycs (Mus musculus) | 6480464 | CTD | Doxorubicin results in increased secretion of CYCS protein | PMID:37453608 | Cycs | multiple interactions | ISO | Cycs (Mus musculus) | 6480464 | CTD | [Doxorubicin co-treated with Dexrazoxane] results in increased expression of CYCS mRNA; Metformin inhibits the reaction [Doxorubicin results in increased secretion of CYCS protein] | PMID:26873546 PMID:37453608 | Cycs | multiple interactions | ISO | CYCS (Homo sapiens) | 6480464 | CTD | [Doxorubicin co-treated with Phellinus linteus extract] affects the localization of CYCS protein; Morphine inhibits the reaction [Doxorubicin affects the localization of CYCS protein]; MT3 protein inhibits the reaction [Doxorubicin affects the localization of CYCS protein] | PMID:16868541 PMID:17542780 PMID:19767621 | |
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