GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cycs | decreases expression | EXP | | 6480464 | CTD | Estradiol results in decreased expression of CYCS mRNA | PMID:32145629 | Cycs | increases expression | EXP | | 6480464 | CTD | Estradiol results in increased expression of CYCS protein | PMID:15994367 | Cycs | multiple interactions | EXP | | 6480464 | CTD | [norethindrone enanthate co-treated with Estradiol] results in increased expression of CYCS mRNA; [Progesterone co-treated with Estradiol] results in increased expression of CYCS mRNA; Fulvestrant inhibits the reaction [Estradiol results in increased expression of CYCS protein] | PMID:15994367 PMID:18829022 | Cycs | affects localization | ISO | CYCS (Homo sapiens) | 6480464 | CTD | Estradiol affects the localization of CYCS protein | PMID:16924424 | Cycs | decreases expression | ISO | Cycs (Mus musculus) | 6480464 | CTD | Estradiol results in decreased expression of CYCS mRNA | PMID:19484750 | Cycs | increases expression | ISO | CYCS (Homo sapiens) | 6480464 | CTD | Estradiol analog results in increased expression of CYCS mRNA; Estradiol analog results in increased expression of CYCS protein; Estradiol results in increased expression of CYCS mRNA; Estradiol results in increased expression of CYCS protein | PMID:18354059 PMID:20211987 PMID:31614463 PMID:36460128 | Cycs | multiple interactions | ISO | CYCS (Homo sapiens) | 6480464 | CTD | ESR1 protein affects the reaction [Estradiol results in increased expression of CYCS protein]; fulvestrant inhibits the reaction [Estradiol affects the localization of CYCS protein] | PMID:16924424 PMID:18354059 | |
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