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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2442
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ctf1
Name: cardiotrophin 1
Acc ID: CHEBI:28869
Term: menadione
Definition: A member of the class of 1,4-naphthoquinones that is 1,4-naphthoquinone which is substituted at position 2 by a methyl group. It is used as a nutritional supplement and for the treatment of hypoprothrombinemia.
Chemical ID: MESH:D024483
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ctf1increases expressionISOCtf1 (Mus musculus)6480464CTDVitamin K 3 results in increased expression of CTF1 mRNA; Vitamin K 3 results in increased expression of CTF1 proteinPMID:16507596
Ctf1multiple interactionsISOCtf1 (Mus musculus)6480464CTD2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; 2-methoxyestradiol inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; acetovanillone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; diphenyleneiodonium inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; pyrazolanthrone inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]; U 0126 inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]PMID:16507596
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