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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2402
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Crem
Name: cAMP responsive element modulator
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cremaffects expressionEXP 6480464CTDTetrachlorodibenzodioxin affects the expression of CREM mRNAPMID:34747641
Cremdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of CREM mRNAPMID:21215274 PMID:32109520
Cremincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of CREM mRNAPMID:33387578
Cremaffects expressionISOCrem (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of CREM mRNAPMID:21570461 PMID:24058054
Cremmultiple interactionsISOCrem (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of CREM mRNAPMID:28433925
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