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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2396
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cpt1a
Name: carnitine palmitoyltransferase 1A
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cpt1adecreases expressionEXP 15036816RGDethanol decreases expression of CPT1a mRNA and protein in liver 
Cpt1adecreases expressionEXP 6480464CTDEthanol results in decreased expression of CPT1A mRNAPMID:24146112 PMID:27795452 PMID:29940154
Cpt1amultiple interactionsEXP 6480464CTD3-(3,4-dimethoxyphenyl)propenoic acid inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; [Ethanol co-treated with Dietary Fats] results in increased expression of CPT1A mRNA; dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; Ethanol inhibits the reaction [[Oleic Acid co-treated with Palmitic Acid] results in increased expression of CPT1A protein]; Plant Extracts inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]PMID:21051528 PMID:24146112 PMID:26854922 PMID:27795452 PMID:29940154
Cpt1adecreases expressionISOCpt1a (Mus musculus)6480464CTDEthanol results in decreased expression of CPT1A mRNA; Ethanol results in decreased expression of CPT1A proteinPMID:18755807 PMID:19637192 PMID:20637825 PMID:24146112 PMID:25455889 PMID:28935932 PMID:34995708 PMID:35526736 PMID:36708882
Cpt1adecreases expressionISOCPT1A (Homo sapiens)6480464CTDEthanol results in decreased expression of CPT1A mRNA; Ethanol results in decreased expression of CPT1A proteinPMID:27939985 PMID:29940154
Cpt1aincreases expressionISOCpt1a (Mus musculus)6480464CTDEthanol results in increased expression of CPT1A mRNAPMID:30319688 PMID:32325186
Cpt1amultiple interactionsISOCpt1a (Mus musculus)6480464CTD[Ethanol co-treated with Diethylhexyl Phthalate] results in increased expression of CPT1A mRNA; [Ethanol co-treated with Lipopolysaccharides] results in decreased expression of CPT1A protein; [Rosiglitazone co-treated with Ethanol] results in increased expression of CPT1A mRNA; [Zinc deficiency co-treated with Ethanol] affects the expression of CPT1A mRNA; Berberine inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; Cannabidiol inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; diallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in decreased expression of CPT1A protein]; diallyl disulfide inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; dioscin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; NLRC5 promotes the reaction [Ethanol results in decreased expression of CPT1A mRNA]; Resveratrol inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; tectoridin inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]PMID:18755807 PMID:20007851 PMID:20637825 PMID:24146112 PMID:24155903 PMID:25455889 PMID:28935932 PMID:32325186 PMID:35526736 PMID:36708882
Cpt1amultiple interactionsISOCPT1A (Homo sapiens)6480464CTD3-(3,4-dimethoxyphenyl)propenoic acid inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; [artenimol co-treated with NR1H4 protein] inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; artenimol inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; artenimol inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; NR1H4 protein inhibits the reaction [Ethanol results in decreased expression of CPT1A mRNA]; NR1H4 protein inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]; obeticholic acid inhibits the reaction [Ethanol results in decreased expression of CPT1A protein]PMID:27939985 PMID:29940154
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