GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cp | increases expression | EXP | | 6480464 | CTD | Iron deficiency results in increased expression of CP protein; Iron deficiency results in increased expression of CP protein modified form | PMID:22457245 PMID:23814049 | Cp | multiple interactions | EXP | | 6480464 | CTD | [Zinc co-treated with Iron co-treated with Calcium] inhibits the reaction [lead acetate results in decreased expression of CP protein] | PMID:22534743 | Cp | affects binding | ISO | CP (Homo sapiens) | 6480464 | CTD | CP protein binds to [TF protein binds to Iron] | PMID:21049900 | Cp | decreases export | ISO | CP (Homo sapiens) | 6480464 | CTD | CP gene mutant form results in decreased export of Iron | PMID:20801540 | Cp | increases abundance | ISO | Cp (Mus musculus) | 6480464 | CTD | CP gene mutant form results in increased abundance of Iron | PMID:16988052 | Cp | increases activity | ISO | CP (Homo sapiens) | 6480464 | CTD | Iron deficiency results in increased activity of CP promoter | PMID:10777486 | Cp | increases oxidation | ISO | CP (Homo sapiens) | 6480464 | CTD | CP protein results in increased oxidation of Iron | PMID:12572680 PMID:20655381 | Cp | multiple interactions | ISO | Cp (Mus musculus) | 6480464 | CTD | [CP gene mutant form results in increased abundance of Iron] which results in decreased expression of TFRC mRNA; [CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTH1 mRNA; [CP gene mutant form results in increased abundance of Iron] which results in increased expression of FTL mRNA; [CP gene mutant form results in increased abundance of Iron] which results in increased expression of SLC11A1 mRNA; Iron inhibits the reaction [Diethylnitrosamine results in increased expression of CP protein] | PMID:16988052 PMID:19061943 | Cp | multiple interactions | ISO | CP (Homo sapiens) | 6480464 | CTD | [CP protein results in increased oxidation of Iron] which results in increased stability of SLC40A1 protein; ARNT protein affects the reaction [Iron deficiency results in increased activity of CP promoter] | PMID:10777486 PMID:20655381 | | ||||||||||||||||||||||
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