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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2375
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Col2a1
Name: collagen type II alpha 1 chain
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Col2a1decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of COL2A1 mRNA; Dexamethasone results in decreased expression of COL2A1 proteinPMID:35148621
Col2a1multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Amino Acids]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of Pantothenic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in decreased abundance of phenylpyruvic acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Amino Acids]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Carnitine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Citric Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Creatinine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of phenylacetylglycine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Succinic Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uric Acid]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased abundance of Uridine]; Dexamethasone inhibits the reaction [[COL2A1 protein co-treated with Freund's Adjuvant] results in increased secretion of IL1B protein]PMID:24709313
Col2a1affects expressionISOCol2a1 (Mus musculus)6480464CTDDexamethasone affects the expression of COL2A1 mRNAPMID:21277400
Col2a1decreases expressionISOCol2a1 (Mus musculus)6480464CTDDexamethasone results in decreased expression of COL2A1 mRNA; Dexamethasone results in decreased expression of COL2A1 proteinPMID:29329878
Col2a1decreases expressionISOCOL2A1 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of COL2A1 mRNA; Dexamethasone results in decreased expression of COL2A1 proteinPMID:27608943
Col2a1multiple interactionsISOCol2a1 (Mus musculus)6480464CTDDexamethasone affects the reaction [[Freund's Adjuvant co-treated with COL2A1 protein] affects the activity of GSR protein]; Dexamethasone inhibits the reaction [[Freund's Adjuvant co-treated with COL2A1 protein] results in increased expression of IL1B protein]; Dexamethasone inhibits the reaction [[Freund's Adjuvant co-treated with COL2A1 protein] results in increased expression of IL6 protein]PMID:17299831
Col2a1multiple interactionsISOCOL2A1 (Homo sapiens)6480464CTD[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA; Dexamethasone inhibits the reaction [BMP2 protein results in increased expression of COL2A1 mRNA]; IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA]; PTH protein modified form inhibits the reaction [Dexamethasone results in decreased expression of COL2A1 protein]; resveratrol inhibits the reaction [IL1B protein inhibits the reaction [[TGFB3 protein co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL2A1 mRNA]]PMID:17502159 PMID:26526931 PMID:27608943
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