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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2366
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Abcc2
Name: ATP binding cassette subfamily C member 2
Acc ID: CHEBI:63623
Term: succimer
Definition: A sulfur-containing carboxylic acid that is succinic acid bearing two mercapto substituents at positions 2 and 3. A lead chelator used as an antedote to lead poisoning.
Chemical ID: MESH:D004113
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2increases transportEXP 6480464CTDABCC2 protein results in increased transport of Succimer metabolitePMID:17940195
Abcc2multiple interactionsEXP 6480464CTDABCC2 protein affects the reaction [Succimer binds to and results in increased secretion of [Mercuric Chloride binds to Cysteine]]; ABCC2 protein binds to and results in increased secretion of [Succimer binds to [Mercuric Chloride binds to Cysteine]]PMID:18511429
Abcc2increases transportISOABCC2 (Homo sapiens)6480464CTDABCC2 results in increased transport of Succimer metabolitePMID:19063911
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